{"id":1269,"date":"2017-09-01T06:01:17","date_gmt":"2017-09-01T06:01:17","guid":{"rendered":"https:\/\/www.seasidemedicalpractice.com\/dev\/\/dev\/?p=1269"},"modified":"2017-09-01T06:01:17","modified_gmt":"2017-09-01T06:01:17","slug":"anti-aging-medications","status":"publish","type":"post","link":"https:\/\/www.seasidemedicalpractice.com\/dev\/anti-aging-medications\/","title":{"rendered":"Top 3 Anti-Aging Medications"},"content":{"rendered":"

US Pharmacopia<\/a>, the manuscript of all drugs manufactured nationwide, has hundreds of thousand drugs listed for every imaginable disease out there, of which I have chosen three to discuss in this month\u2019s newsletter for their effects on the aging process.\u00a0 These drugs have very different mechanisms of action, though a shared attribute of proven benefit on reversal of aging.\u00a0 Interestingly, all three anti-aging medications are related to insulin, the hormone that controls blood sugar and builds new tissue.<\/p>\n

By now, almost everyone knows that diabetes<\/a> is bad for your health, affecting a quarter of US population and a leading contributor to heart disease. The deleterious effects of insulin derangement in the body wreaks havoc on our microcirculation, metabolism, and major organs. \u00a0 Insulin resistance causes accelerated aging.<\/p>\n

Jardiance<\/h2>\n

In 2014, astonishing findings of a new anti-diabetic medication, empagliflozin shocked the medical community with results of trial showing 32% reduction in mortality in diabetics who took\u00a0 this pill in addition to standard regimen.\u00a0 In other words, patients had 1-in-3 chance of avoiding death with Jardiance.\u00a0 Contrary to most other anti diabetic agents, which act on insulin metabolism in the liver or pancreas, empagliflozin works on the kidney by blocking the reabsorption of glucose from urine into blood via a kidney tubule receptor known as sodium glucose co-transporter (SGLT-2 ).<\/p>\n

\"MOAIn the past, we always treated diabetics by trying to get glucose out of their urine, where now we are trying to make you urinate more glucose out of the body.\u00a0 No one really knows why or how this particular drug has exhibited life saving benefits to this degree, as similar reductions in diabetes marker with other drugs have not. In the US, there are 3 available SLGT-2 inhibitors but only Jardiance has been studied with respect to prevention of death.
\nSGLT-2 inhibitors also lower blood pressure, uric acid, prostaglandins, and weight.\u00a0 By urinating out calorie rich glucose, and removal of excess fluid, weight loss is typically observed with this class of drugs.\u00a0 SGLT-2 inhibition plays a role in reducing oxidative stress which may account for its anti-aging benefit.<\/p>\n

The risks associated with empagliflozin is yeast infection, dehydration especially when taken with other diuretics, and dangerously low blood sugar. Leg amputation<\/a> was more frequent in a similar drug in this class, canagliflozin (Invokana), but not seen with Jardiance.
\nJardiance is covered by most insurance companies with a monthly copay range between $0-50, or cash price of $415\/30 tabs.<\/p>\n

Metformin<\/h2>\n

In use since the 1950\u2019s, metformin is ADA\u2019s recommended first line treatment for management of type 2 diabetes and one of my all time favorite medications to prescribe.\u00a0 Aside from its highly effective anti-diabetic virtue, metformin has been implicated in cancer prevention, weight loss, and PCOS.\u00a0 In animal models, metformin has proven to expand lifespan. \u00a0When indicated, I find myself reverting to this medication time and time again for both it ease of use, tolerability, cost and anti-aging properties.<\/p>\n

\"moaMetformin affects cellular and mitochondrial processes associated with aging, such as inflammation, oxidative damage, adaptability, and accelerated cell death.\u00a0 In February 2015, researchers from Albert Einstein College of Medicine in New York received approval from the FDA, to study metformin for its \u201canti-aging\u201d\u00a0 benefits in human adults in the MILES trial.
\nNever before has FDA approved any trial for anti-aging.\u00a0 If these scientists are able to show that metformin changes the biology of gene expression in older adults to younger levels, we will have the world\u2019s first and only FDA-approved anti-aging drug.\u00a0 And the best part is, it costs less than a nickel.<\/p>\n

<\/h2>\n

<\/h2>\n

HGH<\/h2>\n

\"acromegaly_page_facial_features\"When I dipped my timid toes into the world of Anti-Aging Medicine* in 2009, I learned about injectable recombinant human growth hormone (HGH) as a drug to enhance youthfulness and vitality.\u00a0 Sure we learned briefly about growth hormone in medical school, how it peaks in youth to help make us grow, then begins a slow descent after the growth spurt is completed around our early 20\u2019s.\u00a0 We also learned from our professors that elevated growth hormone secreted after the growth plates fuse causes acromegaly (Figure 1), conversely not enough secretion during puberty causes short\u00a0 stature.<\/p>\n

But what we were never taught in medical school or residency was the many uses of HGH such as performance enhancement, repair after injury, strength, energy and vitality. \u00a0Our unworldly eyes never saw the workings of this lucrative potion that can reverse the process of aging.
\nWhat I\u2019ve come to learn from nearly a decade of experience prescribing HGH, is a classic tale of a medical gem a whole lot of us could use, but only a few are afforded.\u00a0The role HGH has on anti-aging may not be evident in every patient, which explains the contradiction that exists between research findings and what is anecdotally reported.<\/p>\n

Fun facts about growth hormone (GH)<\/h2>\n

\"growthGH is released by the pituitary gland in pulsatile fashion throughout the day, but mostly at night.\u00a0 Because of its extremely short half-life, levels are generally not measured in routine blood panel.\u00a0 Instead we check IGF-1 level \u00a0(Insulin-like Growth Factor-1), a substance released by the liver in response to GH stimulation.\u00a0 Tony Robbins has reportedly an IGF-1 level several times the upper limit of normal, from a hyper secreting pituitary adenoma, which many doctors except one advised him to surgically remove.\u00a0 The last doctor told him his greatness is due to this aberrancy and to not let anyone mess with it.<\/p>\n

Although not perfectly understood, the anti-aging properties of low dose recombinant human growth hormone in adults, is believed to be in part related to its hypertrophic effects on lean body mass by stimulating protein synthesis, as well as hydrophilic or \u201cwater-loving\u201d effects within the cells. HGH causes muscles cells to become stronger not necessarily bigger, by increasing their water content, making them plump and well hydrated.\u00a0 Improvement in exercise performance (VO2 max, ventilatory threshold, and muscle strength) is seen with HGH in adults with GH deficiency.\u00a0 Similar performance enhancement was seen when HGH was used in combination with testosterone in elderly men, a population known to have relatively low levels of these hormones.\u00a0 The landmark study of Rudman in 1990 showed that GH administration in elderly men results in increased lean body mass and decreased fat\/muscle ratio.\u00a0 Several other studies which followed further defined its properties.\u00a0 In fact, there is now evidence that HGH has anticatabolic activity as opposed to anabolic activity, meaning this hormone will prevent muscle cells from breaking down rather than make new muscle cells.
\nGH has many other non-muscle enhancing properties as well, like lipolysis, fat burning, bone turnover and collagen synthesis. \u00a0 When utilized for performance enhancing, it may decrease risk of injury by strengthening joints, and increasing bone resilience.
\nThere are risks associated with GH administration, most importantly, a big dip in the wallet.\u00a0 If you\u2019re thinking about utilizing HGH for any of the benefits discussed here, first begin by checking your IGF-1 level, and then expect to invest a good chunk of change to maintain your youthful vitality.<\/p>\n

In good health and a youthful mind,
\nDr. Yazdani<\/p>\n

*There is no medically recognized society of Anti-Aging, but for all intents and purposes, the word rings true with many practitioners who utilize various medications and supplements as an elixir to promote healthy aging and attempt to reverse accelerated aging in their respective patient population.
\nreferences upon request<\/p>\n

You can also click here<\/a> to learn more about Seaside Medical and the services offered!<\/p>\n","protected":false},"excerpt":{"rendered":"

US Pharmacopia, the manuscript of all drugs manufactured nationwide, has hundreds of thousand drugs listed for every imaginable disease out there, of which I have chosen three to discuss in this month\u2019s newsletter for their effects on the aging process.\u00a0 These drugs have very different mechanisms of action, though a shared attribute of proven benefit […]<\/p>\n","protected":false},"author":1,"featured_media":24356,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"none","_seopress_titles_title":"Top 3 Anti-Aging Medications - Jardiance, Metformin, & More","_seopress_titles_desc":"If you've ever considered anti-aging supplements, read on here to learn about the top 3 anti-aging medications you can try. Contact us with questions!","_seopress_robots_index":"","_et_pb_use_builder":"off","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[41,83],"tags":[],"class_list":["post-1269","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aesthetics","category-hormone-therapy"],"_links":{"self":[{"href":"https:\/\/www.seasidemedicalpractice.com\/dev\/wp-json\/wp\/v2\/posts\/1269","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.seasidemedicalpractice.com\/dev\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.seasidemedicalpractice.com\/dev\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.seasidemedicalpractice.com\/dev\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.seasidemedicalpractice.com\/dev\/wp-json\/wp\/v2\/comments?post=1269"}],"version-history":[{"count":0,"href":"https:\/\/www.seasidemedicalpractice.com\/dev\/wp-json\/wp\/v2\/posts\/1269\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.seasidemedicalpractice.com\/dev\/wp-json\/wp\/v2\/media?parent=1269"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.seasidemedicalpractice.com\/dev\/wp-json\/wp\/v2\/categories?post=1269"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.seasidemedicalpractice.com\/dev\/wp-json\/wp\/v2\/tags?post=1269"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}