{"id":10681,"date":"2020-12-05T01:06:01","date_gmt":"2020-12-05T01:06:01","guid":{"rendered":"https:\/\/www.seasidemedicalpractice.com\/dev\/\/dev\/?p=10681"},"modified":"2020-12-05T01:06:01","modified_gmt":"2020-12-05T01:06:01","slug":"nad-infusion","status":"publish","type":"post","link":"https:\/\/www.seasidemedicalpractice.com\/dev\/nad-infusion\/","title":{"rendered":"NAD+ Infusion"},"content":{"rendered":"

Nicotinamide Adenine Dinucleotide aka NAD<\/b>+<\/sup><\/b><\/span><\/p>\n

At Seaside, we pride ourselves for discovering and implementing breakthrough therapeutics in the clinical setting, and we postulate that NAD+<\/sup><\/span> supplementation is the emerging wonder in the world of Anti-Aging and Cognitive Prowess.\u00a0 <\/span>A great body of evidence coupled with advancements in pharmaceuticals has facilitated our ability and strengthened our confidence in offering intravenous infusion of NAD+<\/sup><\/span> to our patient population.\u00a0 <\/span>We now have a viable option to restore energy, vitality and mental clarity in the face of physiologic and environmental stressors.<\/p>\n

What is NAD<\/b>+<\/sup><\/b><\/span>? <\/b><\/p>\n

NAD+ <\/sup><\/span>is synthesized in the cells with NAD+<\/sup><\/span> precursors such as tryptophan, and different forms of Vitamin B3.\u00a0 <\/span>Tryptophan builds NAD+<\/sup><\/span> de novo through the kynurenine pathway.\u00a0 <\/span>Tryptophan is also the starting substrate for serotonin and melatonin production (hence why that Thanksgiving turkey made you sleepy).<\/p>\n

Vitamin B3 consists of nicotinic acid found in plants and algae, nicotinamide, a by-product of pyridine nucleotide, and nicotinamide riboside found in milk.\u00a0 <\/span>Fig 1<\/b><\/p>\n

\"NAD<\/p>\n

These vitamins build NAD+<\/sup><\/span> with help of several other factors, including the gut microbiome.<\/p>\n

What are the biological roles of NAD<\/b>+<\/sup><\/b><\/span>?<\/b><\/p>\n

Many processes in the body depend on NAD+<\/sup><\/span> including cholesterol synthesis, glutathione generation, DNA repair and gene expression, adaptive stress responses, maintenance of calcium homeostasis, ATP generation and most importantly control of lifespan through the sirtuin pathway.<\/p>\n

ENERGY<\/b> – One way NAD+ <\/sup><\/span> controls cellular energy is by serving as a reservoir for hydrogen ions involved in REDOX reactions in the mitochondria.\u00a0 <\/span>The REDOX reaction produces ATP, the \u201cenergy currency\u201d of the body.\u00a0 <\/span>Without adequate stores of NAD+<\/sup><\/span>, this reaction slows down and ATP production declines. Perturbations in mitochondrial function leads to genomic instability which ultimately leads to cell demise.<\/p>\n

AGING<\/b> – In addition to being the regulator of metabolic processes in the body, NAD+<\/sup><\/span> also aides sirtuins, a class of enzymes that regulate our genes and protect the cells from dying prematurely.\u00a0 <\/span>Sirtuins play a pivotal role in longevity and accelerated aging, and they need an optimal amount of NAD+<\/sup><\/span> to function.<\/p>\n

With over 500 processes in the body dependent of adequate concentrations of NAD+<\/sup><\/span>, it is no wonder it has become a salient area of research for targeted therapies towards degenerative diseases such as Alzheimer\u2019s and chronic inflammatory conditions.<\/p>\n

What reduces NAD<\/b>+<\/sup><\/b><\/span> production? <\/b><\/p>\n

When the production of NAD+ <\/sup><\/span>declines or the consumption is too high, there is an imbalance of supply and demand.\u00a0 <\/span>The demand may be acute such as excessive DNA damage from free radicals or UV attack, or from chronic inflammatory states.\u00a0 <\/span>Accumulation of oxidative stress in the aged population also depletes NAD+<\/sup><\/span> stores.\u00a0 <\/span>High fat diet, deficiency in vitamin B3 or B6 or tryptophan decrease production of NAD+<\/sup><\/span>.<\/p>\n

What increases NAD<\/b>+<\/sup><\/b><\/span> production? <\/b><\/p>\n

Caloric restriction, exercise, glucose deprivation, resveratrol, adequate intake of vitamin B3, vitamin B6 and tryptophan, as well as NAD+<\/sup><\/span> precursors such as NMN or NR.<\/p>\n

In a seminal paper on NAD+<\/sup><\/span> released in January 2019, the authors postulate that NAD+ <\/sup><\/span>supplementation may lead to beneficial effects on brain, cardiac, and renal function under various stressors, and that intravenous administration of NAD<\/i>+<\/sup><\/i><\/span> is the only effective means of clinically increasing system NAD<\/i>+<\/sup><\/i><\/span> levels.<\/i>1<\/sup><\/i><\/span><\/p>\n

What is the process of NAD infusion? <\/b><\/p>\n

NAD comes in an injectable form or diluted in solution for intravenous delivery.\u00a0 <\/span>The injection may be administered at home intramuscularly with a 25 gauge needle.\u00a0 <\/span>The intravenous solution contains 400mg of pure NAD+<\/sup><\/span> which is then infused over 2- 2.5 hours.\u00a0 <\/span>The effects are immediate, and may be repeated every week or every month thereafter.\u00a0 <\/span>Treatment intervals are yet to be elucidated, and likely will depend on each individual\u2019s response.\u00a0 <\/span>Adverse effects during the infusion are nausea, shortness of breath, chest tightness and rapid heart rate.\u00a0 <\/span>These effects subside while receiving the infusion or shortly thereafter.<\/p>\n

Candidates most suitable for this procedure are essentially anyone interested in boosting cellular energy metabolism in their body.\u00a0 <\/span>Those with chronic illness, chronic inflammatory condition, accelerated aging, elderly, athletes, fatigue, addiction may benefit the most from even just one session.<\/p>\n

My experience after a single session of intravenous NAD+<\/sup><\/span> was profound.\u00a0 <\/span>It was like pressing the boost button on my brain.\u00a0 <\/span>I had an immediate sense of wellbeing, energy, mental clarity, vision enhancement, and a renewed zest for life! Others have described their NAD experience in similar ways:<\/p>\n